We spent 4 months testing 5 top-rated thermogenic supplements for weight loss. Which one is currently #1?

Gaining weight for seemingly no reason. Especially around the belly.

That’s the #1 issue our readers reported in the recent Health Insider survey.

Second place?

“Being unable to lose that weight and keep it off no matter how much I diet and exercise.”

And it all actually makes complete sense.

Because scientists recently discovered that women over 40 develop something called “thermogenic resistance.”^1,2

This condition is caused by hormonal changes and aging.

And it literally forces your body to store calories from food around the stomach instead of burning them 24/7.

But the main issue is that typical ways to boost thermogenesis, like cold exposure and HIIT training, aren’t sustainable.

So we ran a 4-month test with 60 women struggling with stubborn weight.

The goal: find the best supplement that tackles “thermogenic resistance” and reactivates thermogenesis.

We tested:

• Bioma Night Metabolism & Sleep
• Inno Shred™ GLP-1
• Citrus Burn
• Thermogenic Sculpt
• Vital Reds®

These 60 women were separated into 5 groups and took each supplement for 4 months.

We tracked results using weekly weigh-ins and self-reports on:

• Total weight loss
• Waistline reduction
• Side effects

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#1 — Bioma Night Metabolism & Sleep

The only supplement that started working so quickly and helped testers lose the most weight without any issues

What it is

A sophisticated supplement that stacks four thermogenic ingredients — CLA, L-theanine, green coffee, and ashwagandha — each reactivating thermogenesis through a different mechanism.^3,4,5,6

How it worked

This was the only supplement that made women who took it for 4 months say, “I’ll 100% keep using it after this test ends.” Bioma started working quickly and caused zero issues. It helped testers lose weight, get rid of belly fat, and improve their sleep quality (a nice extra benefit).

Price: $22.99 (currently 35% off, normally $35.37)

Data from weigh-ins and self-reports:

• Average total weight loss: 34 lbs

• Average waistline reduction: 5.8 inches

• Side effects: None reported

Pros

• Stacks four thermogenic ingredients — more than any other supplement tested

• Each ingredient reactivates thermogenesis through a different mechanism

• Delayed-release capsules deliver all ingredients intact for maximum benefits

• Costs less than $1/day with the current discount and causes zero side effects

Cons

Sells out often because of the high demand (especially during sale events)

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#2 — Inno Shred™ GLP-1

Contains a genuinely strong thermogenic ingredient, but stimulant-heavy

What it is

A potent supplement built around Paradoxine, which is one of the few botanicals proven to increase thermogenesis.⁷

How it worked

Testers in the Inno Shred group lost a meaningful amount of weight — the second most of all five groups. But the stimulant stack took its toll. Most testers reported jitters and afternoon crashes, while some experienced palpitations and deteriorated sleep quality.

Price: $69.99

Data from weigh-ins and self-reports:

• Average weight loss: 29 lbs

• Average waistline reduction: 3.7 inches

• Side effects: Palpitations, poor sleep, anxiety

Pros

• Paradoxine (Grains of Paradise extract) is a powerful thermogenic ingredient

• Second-strongest weight loss results in this 4-month test

Cons

• Almost 3 times more expensive than the winner of this test

• Some testers reported palpitations, disrupted sleep, and anxiety

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#3 — CitrusBurn™

Two thermogenic compounds, but its headline ingredient is its weakest link

What it is

A relatively new supplement formulated with Capsaicin and Seville Orange Peel.

How it worked

Testers saw a pretty significant weight loss, but it was far from the previous two groups. It’s because recent studies found that the thermogenic effects of Seville Orange Peel are frequently driven by co-ingredients rather than this compound itself.^8,9

Price: $79.00

Data from weigh-ins and self-reports:

• Average weight loss: 19 lbs

• Average waistline reduction: 2.8 inches

• Side effects: None reported

Pros

• Capsaicin is one of the most studied thermogenic compounds

• Testers didn’t experience any side effects

Cons

• Flagship ingredient p-synephrine has modest thermogenic effects at best

• The minimum order quantity is two bottles instead of just one

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#4 — Thermogenic Sculpt

Boosts thermogenesis through three ingredients, but pushes the nervous system into overdrive

What it is

A stimulant-heavy supplement formulated on three thermogenic compounds — caffeine anhydrous, theobromine, and guarana.^10,11,12

How it worked

Testers noticed thermogenic effects early on and lost a lot of weight. But the stimulant load was simply too aggressive for most women in this group. Jitters, racing heart, and disrupted sleep were reported with several testers asking to stop before this 4-month test ended.

Price: $65.97

Data from weigh-ins and self-reports:

• Average weight loss: 24 lbs

• Average waistline reduction: 3.4 inches

• Side effects: Jitters, racing heart, sleep disruptions

Pros

• All three core ingredients are proven to increase thermogenesis

• Noticeable thermogenic effects and weight loss early on

Cons

• May push the nervous system into overdrive

• Several testers asked to stop early due to jitters, poor sleep, and a racing heart

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#5 — Vital Reds®

Impressive-looking list of ingredients, but spreads too thin to target thermogenesis meaningfully

What it is

A sophisticated supplement with over 30 fruit and berry extracts, a “Metabolic Enhancing Blend,” and probiotics.

How it worked

Weight loss results were the weakest in this group by a significant margin. The core problem is that spreading one formula across 30+ compounds leaves no single ingredient at a dose that can meaningfully target thermogenesis.

Price: $44.95

Data from weigh-ins and self-reports:

• Average weight loss: 12 lbs

• Average waistline reduction: 1.7 inches

• Side effects: None reported

Pros

• Contains green and white tea extracts that are proven to boost thermogenesis

• Great for energy, digestion, and overall wellness

Cons

• Weakest weight loss results of this test

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Final word

Every thermogenic supplement helped these 60 women lose weight — but one of them clearly stood out during this 4-month test.

Bioma Night Metabolism & Sleep helped testers lose 34 pounds on average and trim down 5.8 inches from their waist.

So, if you’re 40 or older and struggle with “thermogenic resistance” and stubborn weight, this is the supplement we’d recommend.

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Try Bioma to reactivate thermogenesis and lose stubborn weight without any risk

Bioma Night Metabolism & Sleep is backed by rigorous science and trusted by over 34,990 people who have collectively lost 414,900+ pounds already.

✅ 35% off — now $22.99 instead of $35.37
✅Targeted thermogenesis support
✅ Consistent and sustainable weight loss
✅ Significant waistline reduction
✅ No jitters, palpitations, or side effects
✅ Free nationwide shipping
✅ 4.2 ★ on Trustpilot