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Best GLP-1 Supplements of 2026

check Last Updated - 2026-06-23
Written by Alexandra Pierce, MD 🇺🇸 Written by Alexandra Pierce, MD 🇺🇸

Tested & Approved

Consumers’ Reviews

star star star star star

Ozempic isn’t for everyone.

It’s expensive, insurance doesn’t always cover it, and it can have nasty side effects.

So we ran a 3-month test on the three most popular GLP-1 boosting supplements.

The subjects? 59 women struggling with unexplained weight gain, stubborn belly fat, and irresistible cravings.

And only one supplement delivered an average of 32lbs of weight loss.

#1

Bioma

Best Choice in 2026
Bioma

PROS

  • Spikes GLP-1 in just 10 minutes
  • 2x increase in GLP-1 secretion
  • Supports natural GLP-1 production long-term
  • Reduces hunger and cravings
  • Helps burn stubborn belly fat
  • Boosts energy without jitters or crashes
  • Improves digestion and reduces bloating
  • Delayed-release capsules
  • No prescription, injections, or side effects
  • Costs less than $1/day

CONS

  • Often out of stock due to high demand
ReviewScore 9.8
Excellent 9,137 Customer Reviews
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#2

Pendulum GLP-1 Probiotic

Pendulum GLP-1 Probiotic

PROS

  • Uses clinically-proven probiotic strains
  • Formulated to produce butyrate in the gut
  • Takes a similar approach to #1

CONS

  • Takes 3-4 weeks to start working (slower onset)
  • Some users reported digestive issues and fatigue
  • Hair loss reported in a small percentage of users
  • Weaker results compared to top option (23 lbs vs 32 lbs average)
  • More expensive ($70/month)
  • Missing key supporting ingredients for faster results
ReviewScore 8.1
Excellent 6,783 Customer Reviews Customer Reviews
#3

Advanced Bionutritionals GLP-1 Plus

Advanced Bionutritionals GLP-1 Plus

PROS

  • Kills sugar cravings
  • Berberine supports GLP-1 production
  • Very few reported side effects
  • Good for those with intense sweet tooth

CONS

  • Most expensive option tested ($99.95/month)
  • Only raises GLP-1 while actively taking it (no long-term effect)
ReviewScore 7.8
Very Good 5,921 Customer Reviews Customer Reviews

We Tested the 3 Best-Selling GLP-1 Supplements. Here’s Why Bioma is #1:

Limited Time Sale: 35% Off Bioma

When we were selecting the three GLP-1 supplements to test, we were particularly excited about Bioma.

 

Because unlike the other two, Bioma claims to have helped 338,000 women lose over 2 MILLION pounds combined.

 

Promises that big usually don’t hold up, but we threw it into our 3-month trial given all the recent buzz.

 

And it didn’t disappoint!

 

Our users experienced an average weight loss of 32 lbs.

 

Way more than the 21-23 lbs we saw with the other “top-rated” GLP-1 supplements we tested (which also came with side effects we’ll get into later.)

 

And nearly every woman said they’d keep using it after the test ended.

 

Here’s what makes Bioma special…

Instead of trying to mimic GLP-1 with synthetic compounds, Bioma supports your gut’s natural ability to produce it (yes, that’s where GLP-1 is made!).

 

It does this through butyrate – a short-chain fatty acid your gut bacteria produce when they’re healthy and well-fed.

 

Studies show butyrate can spike GLP-1 levels twofold in just 10 minutes. Perfect for shutting down cravings fast.1,2

Here’s how it works:

 

First, Bioma contains 9 billion CFU of Bifidobacterium strains that produce butyrate naturally in your gut.

 

Second, it has Xylooligosaccharides (XOS) – a prebiotic that feeds those bacteria and independently produces butyrate.That’s why studies show that XOS increases circulating levels of GLP-1.3,4,5

 

Third, Bioma has Tributyrin –  a superior form of butyrate that breaks down slowly in your gut, releasing a steady stream throughout the day for sustained GLP-1 production.6,7


Plus, it all comes in delayed-release capsules. This means the ingredients survive your stomach acid and actually reach your gut where GLP-1 is made.

 

With Bioma, you’re not just getting a short-lived GLP-1 boost. You’re training your gut to produce more of its own GLP-1 long-term.

 

Prescription GLP-1s don’t do that. Neither did the other supplements.

 

The other two supplements we tested don’t do this. And GLP-1 drugs, though obviously effective, don’t take that kind of root cause approach.

 

So we had to put Bioma to the test to see if it truly lives up to the hype.

 

Here’s what happened:

 

Our Test Results

 

The women in our test took Bioma consistently for three months and the results were surprising.

 

Within the first week, most of them reported a significant drop in sugar cravings.

 

Women who normally reached for candy bars or chips in the afternoon… suddenly didn’t want them anymore.

 

By week two, the mindless snacking between meals basically stopped. No grazing when they got home from work. No late-night raids on the pantry.

 

And by the end of the first month? The average weight loss was 8 pounds.

 

The only thing they changed was taking Bioma daily. Just two tiny capsules… and it was like their bodies remembered how to work again.

 

Now let’s talk about the long term.

 

After three months, the results were undeniable. Our participants lost an average of 32 pounds.

 

Their digestion improved. Energy levels stayed steady throughout the day.

 

And nobody experienced the side effects we saw with some of the other supplements.

 

(No jitters. No hair loss. No digestive issues.)

 

But we wanted to be thorough. So we had them continue for two more months.

 

And the results only got better…

 

In the end, Bioma was better than anything we could have imagined. Who’d have thought a natural GLP-1 booster could work this well!

 

But why did Bioma work when other supplements didn’t? Let’s compare them: 

1. Science: Most GLP-1 supplements use berberine, which only works while you’re taking it. Bioma delivers butyrate which can increase GLP-1 two fold in just 10 minutes. Plus, it trains your gut to make more GLP-1 on its own long-term.

Other probiotic competitors use the wrong strains or low doses. Bioma uses 9 billion CFU of clinically-studied Bifidobacterium strains plus XOS and tributyrin for maximum butyrate production. And the delayed-release capsules ensure everything reaches your gut where GLP-1 is made.

2. Results: Bioma shut down the food noise fast. The longer we took Bioma, the better it worked. Fewer cravings. More energy. Steady weight loss that actually stuck. The other supplements took weeks to kick in and faded over time. That’s why women who took Bioma lost 9–11lbs more on average.

3. Side Effects: Every other supplement we tested caused digestive issues, fatigue, jitters, or even a little hair loss (which freaked us out). With Bioma? Nothing. The probiotic strains are clinically studied, the delayed-release capsules prevent stomach upset, and there are no stimulants or harsh ingredients.

Out of the 3 GLP-1 supplements we tested, Bioma is the only one we’d actually recommend. It works fast, the results last, and there are literally no downsides. 

Value

Bioma is just $26.14 per month with their 35% discount. That’s less than a dollar per day. Which is a steal considering how effective it is at shutting down cravings and speeding up weight loss.

 

Advanced Bionutritionals GLP-1 Plus cost $99.95 per month. Inno Shred GLP-1? $79.99. UMZU Sensolin GLP-1 was more reasonable at $34.99 (but it did nothing) and Pendulum GLP-1 Probiotic sits at $70.00.

 

A Better Way To Lose Weight And Feel Good In Your Body Again 

At the heart of Bioma is its unique approach to GLP-1 production, designed to help your gut produce more of this weight loss hormone naturally.

 

It’s all the GLP-1 benefits without the side effects, prescriptions, or $1,000+ monthly price tag.

 

It kills cravings, improves digestion, reduces bloating, boosts energy, and supports overall gut health.

 

If you’ve tried everything but still couldn’t lose weight and keep it off, this is the supplement we’d recommend hands down.

 

Lost 23 lbs

I went in super skeptical but was actually pleasantly surprised. I used to weigh 185lbs and now I’m 162lbs. Lost 23lbs without any major changes to my lifestyle (I did follow a more balanced diet but it was much easier cause my cravings have subsided). Worth every penny.

Emma B. – New York

★★★★★

Lost inches off my waist

I love how this is made from clean ingredients and works with your body, not against it. I’ve been using this product for 2 months now and I noticed positive changes in my gut health, and even lost inches off my waist (together with a healthy diet). I’m also a lot less hungry than I used to be. I’m a biiig time late night snacker and this product helped A LOT with that. Definitely worth a try if you have struggled to lose weight so far.

Meghan P. – Boston

★★★★★

Fewer cravings for junk food

These absolutely do what they say. I have fewer cravings for junk food and my weight has also dropped. It really helps with tiredness as well, my energy is a lot more stable throughout the day. Recommend!

Kristy M. – Las Vegas

★★★★★

Purchase and Delivery Process

Getting Bioma is really simple.

 

Since Bioma is sold exclusively online, you’re getting it at an affordable price without the markups you’d find in stores.

 

When we placed our order, it arrived just 3 days later. This was the fastest delivery out of all the supplements we tested.

 

And the 35% discount was already applied at checkout, so there was no need to mess around with typing in discount codes or searching for deals. It was all done for us, which made the whole process even easier.

 

Where Can I Buy Bioma?

Getting your own Bioma with up to 35% off is simple. Just follow these steps:

  1. Go to the official Bioma website.
  2. Choose the number of bottles you want (the more you buy, the bigger the discount);
  3. Enter your shipping and payment details
  4. Confirm your order and start supporting your body’s natural GLP-1 production!
#1
product
Review Score 9.8
Excellent 9,137 Customer Reviews Customer Reviews
Science 10
Results 10
Safety 10
Value 9

#1 GLP-1 Supplement of 2026

Bioma supports your gut’s natural GLP-1 production through clinically-studied probiotic strains, butyrate delivery, and delayed-release capsules. It delivers fast craving control, more energy, less bloating and sustained weight loss – without expensive injections or unwanted side effects.

 

💝 4,184 people bought this week

 

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Comments (3)

  1. avatar
    Jennifer M.
    23 Jun, 2026 at 8:30 pm

    I’ve been researching GLP-1 supplements for WEEKS and this is the most thorough comparison I’ve found. The fact that you actually TESTED them for 3 months with real people instead of just comparing ingredient labels makes this so much more trustworthy. Ordering Bioma now!

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  2. avatar
    sarah_k
    20 Jun, 2026 at 4:01 pm

    32 lbs average vs 21-23 lbs with the others is a huge difference. that’s nearly 50% more weight loss

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  3. avatar
    LisaR
    17 Jun, 2026 at 8:30 pm

    I tried Pendulum last year and it took FOREVER to start working. Plus I was exhausted all the time. Switching to Bioma based on this review – the fact that it works in 10 minutes for cravings is exactly what I need

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